The stem cell clinic Diaries
Modest-molecule inhibitors with the serine dipeptidases DPP8 and DPP9 (DPP8/9) induce a lytic method of cell Demise called pyroptosis in mouse and human monocytes and macrophages1,2. In mouse myeloid cells, Dpp8/nine inhibition activates the inflammasome sensor Nlrp1b, which in turn activates pro-caspase-1 to mediate cell death3, though the system